I should think most of us still are GMs

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I have a thread in the Suggestion box where I also say that the original Disciplines can work perfectly in a computer game, no need to convince me

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As for the you controling NPCs - it isn't that simple. Yes it is about hierarchy, politics, and power, not just: aiming/shooting, running/slashing/punching, but over a large portion of time during which the Kindred develop the skills they need. That is why many GMs give considerable down time for the characters to learn and use their new traits. Neonates stay at the bottom of the ladder for a considerable amount of time.
Using Disciplines are also not a crutch for vampires. They take time to research, break the Masquerade and should not be used lightly. That is why vampires invest time in Charisma, Appearance, Intimidation, Manipulation and Subturfuge, instead of maxing out Dominate and Presence. That is why they learn Perception, Alertness, Empathy and Investigation instead of using Auspex and Eyes of Chaos all the time. Anything else will turn them into superheroes.
Actually most of the quest in the original VTMB could work with pen-n-paper's disciplines. Hospital's quest (taking the werewolf blood, finding lily, etc.) could be completed by using domination and actually controlling someone to make the job for you, this also available for astrolite's quest, museum etc. With the real auspex discipline you should be able to know when someone have something he didn't tell you in mind ( Gimble, Hengeyokai) or if there is something of interest in a room.
There are two reasons why this should not work quite like that.
The first is that to be able to do that most likely you would need the highest dots in the Disciplines Possession and the four dots in Telepathy. This is optimistic seeing as though they are among the first quests in the game.
The second reason is, if my lore reasoning is ignored, most quests can be completed this way. If nobody ever finds out you use Disciplines for everything no social combat and no stealth missions will exist. You can just Dominate a person to bring you the manifest to the Elizabeth Dane and to tell you about the Sarcophagus, you can learn about the whereabouts of Bertram without dealing with the twins, and if a random roll system was implemented, you could just reload until the Dominate attempt is succeeded. It's a slippery slope.
That said these Disciplines do have their place in the game, but it should be scripted responsibly, in a manner that a true Kindred would (supposedly) use. It would be the best of both worlds if more social combat was added, so you get have your politics and power play without expending vitae. A sense of building a lasting relationship with the city, not just following the elders' whims, something which was lacking in VtMB.
And for the day/night cycle - no Twilight, please no, never said anything remotely similar to that

. I was not concerned that it would be hard for the players, it would be most welcome. I was concerned that it would probably take a lot of work and a lot of scripting just so we can have this mechanic with which we barely interact. I would suggest levels that include daylight which will basically have the same effect to bring the authentic WoD atmosphere. That way we have a nice change of pace and the feel of true vampiric unlife.
I hope we're on the same page on this one. Peace