While VtM:Bloodlines had a fair bit of balance, some understandable changes were made to the classic Disciplines. I always thought that was kinda disappointing seeing as though they didn't even try to explain why the main character could develop them so differently then the canon in the books.
But now that a Multiplayer is planned there is chance to see more of the classic disciplines, seeing as they are kinda the pillar of Vampire supremacy over one another and I would argue that every single one can be incorporated in the game and serve a viable function.
For example Thaumaturgy:Path of Blood
* A taste of Blood - It can be used to realize how much blood a vampire has currently, and other information like for example his Disciplines. Success at this Discipline should vary accordingly. Also diseased mortals could be implemented and Tremere could be the only ones to easily spot them out and not get infected.
** Blood Rage - as in the game
*** Blood of Potency - It would be cool if the original intent of the Discipline was implemented - bigger Blood pool and a chance to spend more of it of Blood Buff. Accordingly Blood Buff can be made more powerful and much more draining.
**** Theft of Vitae - Blood Strike can be repurposed for this, though the animation has to be tweaked a little.
*****Cauldron of Blood - Should be made in a high-risk, high-reward melee attack.
The only limitations that exist stem from the fact that some Disciplines like Dominate, Presence and Auspex are very social. Though I do think all of them would work in a computer game, atleast on mortal NPCs, the scope, themes and mechanics of the game should (if you want them included) match the Disciplines.
I hope that this topic can give ideas for an efficient and cool way the original intended Disciplines can be incorporated in the game. Anyone?